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| Portugal - Segunda Liga | Tondela | 2 - 3 | Nacional | Double Chance - Draw/Away | |
| Italy - Serie A | Lazio | 2 - 0 | Empoli | Match Winner - Home | |
| Poland - I Liga | Arka Gdynia | 1 - 0 | Zaglebie Sosnowiec | Match Winner - Home | |
| Belgium - Jupiler Pro League | Gent | 0 - 1 | OH Leuven | Match Winner - Home | |
| Denmark - Superliga | Randers FC | 2 - 2 | Hvidovre | Match Winner - Home | |
| Netherlands - Eredivisie | NEC Nijmegen | 2 - 3 | Feyenoord | Double Chance - Draw/Away | |
| Netherlands - Eredivisie | Fortuna Sittard | 1 - 1 | PSV Eindhoven | Match Winner - Away | |
| Netherlands - Eredivisie | Utrecht | 0 - 1 | Sparta Rotterdam | Double Chance - Home/Draw | |
| Spain - La Liga | Atletico Madrid | 1 - 0 | Celta Vigo | Match Winner - Home | |
| Serbia - Super Liga | FK Partizan | 3 - 0 | Mladost Lucani | Match Winner - Home | |
| Belarus - Premier League | Torpedo Zhodino | 2 - 1 | Naftan | Match Winner - Home | |
| England - Premier League | Manchester United | 0 - 1 | Arsenal | Match Winner - Away | |
| Germany - Bundesliga | Bayern Munich | 2 - 0 | VfL Wolfsburg | Match Winner - Home | |
| Turkey - Süper Lig | Fenerbahce | 3 - 0 | Kayserispor | Match Winner - Home | |
| Denmark - Superliga | FC Midtjylland | 2 - 1 | Aarhus | Match Winner - Home | |
| Turkey - Süper Lig | Fatih Karagümrük | 2 - 3 | Galatasaray | Match Winner - Away | |
| Turkey - Süper Lig | Trabzonspor | 3 - 0 | İstanbulspor | Match Winner - Home | |
| Italy - Serie A | Juventus | 1 - 1 | Salernitana | Match Winner - Home | |
| Portugal - Primeira Liga | Benfica | 5 - 0 | Arouca | Match Winner - Home | |
| Germany - Bundesliga | Vfl Bochum | 0 - 5 | Bayer Leverkusen | Double Chance - Draw/Away | |
| Denmark - Superliga | FC Nordsjaelland | 4 - 1 | Silkeborg | Match Winner - Home | |
| France - Ligue 1 | Strasbourg | 2 - 1 | Metz | Double Chance - Home/Draw | |
| France - Ligue 1 | Marseille | 3 - 1 | Lorient | Match Winner - Home | |
| France - Ligue 1 | Paris Saint Germain | 1 - 3 | Toulouse | Match Winner - Home | |
| France - Ligue 1 | Montpellier | 0 - 2 | Monaco | Double Chance - Draw/Away | |
| France - Ligue 1 | Nantes | 1 - 2 | Lille | Double Chance - Draw/Away | |
| Spain - La Liga | Real Betis | 3 - 2 | Almeria | Match Winner - Home | |
| Portugal - Primeira Liga | FC Porto | 2 - 1 | Boavista | Match Winner - Home |